Endocrine Abstracts

The diseases of a thyroid gland belong to the most frequent pathology which is met among people. The prevalence and structure of pathology of a thyroid gland, first of all, depends from the level of a iodine status in the population. The first time the assessment of an iodine status in St Petersburg was carried out in 1999 by the staff of faculty therapy of Saint-Petersburg State Medical University named after academician I.P Pavlov. The median urinary iodine ...

Aim: To access the efficiency of mulitispine computed tomography (MSCT) in ectopic ACTH-syndrome.Patients and methods: Five clinical cases (2 female and 3 male cases) with severe hypercortisolism were analyzed, age from 26 to 63 years old.Results: In all of the 5 cases there were significant reasons to suppose ectopic ACTH-syndrome: rapid development of clinical features (in 4 of 5 cases), loss of lean mass compound with rounded an...

A retrospective cohort study was undertaken using a reproductive health survey of 25 girls aged 14–27 years (Me 20,5 (16;23)) born to bromocriptine-treated mothers. The control group consisted of 25 women born after spontaneous pregnancy of the same age, mother age, region of residence. They were all seen in the clinic for health and psychological interviews (Multiscale Personality Assessment Test- MMPI). All of them were blood analysed for LG, FSG, prolactin, TSH, anti-T...

Objective: To analyze long-term treatment outcomes and to determine prognostic factors affecting the survival of patients with ECS. Matherials and methods: Retrospective, observational study on 147 patients (88 women, 59 men) with ECS diagnosed between 1990 and 2021. Various imaging studies were performed on all patients to find the source of ACTH producing neuroendocrine tumor (NET). Multivariable analysis was performed using a Cox proportional hazards ...

Cushing’s disease (CD) remission after primary surgical treatment is achieved in 70–90%, but recurrence ranges 18–25% after.The aim of this work was to study clinical, hormonal and MRI indicators before and after surgical treatment in patients with recurrent CD to identify possible predictors of recurrence. We examined 49 patients with recurrent CD in the active stage (disease duration up to 3 years). Before neurosurgery blood ACTH (median...

The number of the non-pituitary brain tumors survives increases and will be growing up in the future. Although the prevalence of secondary adrenal insufficiency (SAI) vary depending on the methods of diagnostic, we have a few data about their ACTH and DHAE-S status. The aim of our study was to describe the hypotalamic-pituitary-adrenal axis (HPAA) changes after craniospinal irradiation (CRT) and diagnostic utility basal cortisol (BC), DHAE-S, glucagon stimulation test (GST) in...

Background: Given the technically challenging nature of adrenal venous sampling (AVS) there is a drive to centralise services to improve successful outcomes. This has potential implications for patients living in remote and rural areas.Methods: We retrospectively reviewed the case notes of 15 patients who underwent AVS in our hospital, for investigation of primary hyperaldosteronism between 2002 and 2015. We assessed the success rate of cannulation of th...

Background: TransCon hGH is a long-acting prodrug of recombinant human GH (hGH) that releases into the blood compartment fully active unmodified hGH. TransCon hGH was shown in two Phase 1 studies and a Phase 2 study in AGHD to be safe and well tolerated and inducing an IGF-I pharmacodynamic response within the normal range throughout the dosing period. This interim analysis consists of 25 patients completing all 6 months of treatment.Objectives: The obje...

Introduction: This study evaluates the diagnostic accuracy of clinical features and first line routine screening tests to differentiate ACTH-ectopic syndrome from Cushing’s disease (CD).Materials and methods: The retrospective clinical and biochemical presentations of 180 patients with histologically proven ACTH-dependent Cushing’s syndrome (CS) (159 CD, 21 ACTH-ectopic syndrome) were compared according to the cause of hypercortisolism. ROC-ana...

Introduction: Acromegaly is associated with increased cardiovascular morbidity and mortality, in part, as a consequence of the increased insulin resistance that frequently accompanies GH hypersecretion. Glucose tolerance may worsen in patients treated with somatostatin analogs (SSA).Objective: To compare the long term effects of SSA treatment to successful surgery on glucose metabolism in Cretan acromegalic patients.Design and meth...